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Jacketed Liposome Extruder

Description: The Genizer Jacketed Liposome Extruder is compressed air-driven and temperature-controlled, from testing to manufacturing production of liposome and lipopolyplex, for drug and gene delivery.
Catalog Number: Cat.GJE
Price:
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$4,000.00   Login for Discount
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  • Catalog No.:
    GJE-10mL GJE-100mL GJE-800mL GJE-3000mL GJE-10000mL
  • Gas Connection:
    CGA580 (USA) G5/8 (UK, CN) DIN477 (GE) NF E 29-650/C (FR) UNI4409 (IT)
  • Warranty:
    Standard 1 year 2 year 3 year 4 year 5 year
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  • Description
  • How to Use
Specifications
Description:
The Genizer Jacketed Liposome Extruders is compressed air-driven and temperature-controlled, from testing to manufacturing production of liposome and lipopolyplex, for drug and gene delivery. Homogenous samples can be produced quickly and easily in minutes; typically 5-10 passes are sufficient to produce a sample with uniform liposome size. Genizer Jacketed Liposome Extruders are designed to generate homogeneous unilamellar liposomes and Lipopolyplex. Extrusion is a one-step procedure that produces liposomes by forcing lipid suspensions of drug, protein or gene through track-etched filters of defined pore size. The process is relatively gentle, exposing the formulation to moderate pressures up to 3,000 psi at controlled temperatures. The Genizer Jacketed Extruder offers virtually no dead-volume, is easy to clean, suitable for sterilization and in compliance with FDA and GMP sanitary standards in pharmaceuticals.
 
Application:
Liposome extrusion
 
Performance:
No dead volume
The Jacketed Extruder can control the temperature of the extrusion
 
Specifications
Catalog No. GJE-10mL GJE-100mL GJE-800mL GJE-3000mL GJE-10000mL
Sample Size 10mL 100mL 800mL 3,000mL 10,000mL
Cooling Jacketed Jacketed Jacketed Jacketed Jacketed
Dimensions 23cm×13cm×25cm 23cm×20cm×32cm 25cm×25cm×37cm 30cm×25cm×55cm 45cm×40cm×65cm
Weight 4kg 7kg 20kg 45kg 120kg
Min. Sample Size 5mL 10mL 120mL 800mL 2,000mL
Application Liposome formulation up to production scale
Max. Pressure 3,000 psi-6,000 psi
Max. Temp. 80ºC (176ºF)
Power Type Compressed gas
Nano-membrane Track-etched membrane
Cleaning Flush to clean/CIP/SIP
Sterilization Whole unit autoclavable
 
Standard Features
Parts 1) Liposome Jacketed Extruder 2) 10 pieces of 100nm membrane
Feed Reservoir Temperature-controled jacketed cylinder
Inlet Type 1/4" high pressure coupling
Outlet Type 1/4" high pressure coupling
Nitrogen Tubing G5/8" - 14 TPI BSP inlet nitrogen high pressure soft tubing; adaptor with 3/8-inch male NPT and 1/4-inch female flare outlet
Nano Membrane 100nm track-etched polycarbonate membrane
Compatibility Some parts are compatible with Lipex in Northern Lipids
Product Material 316L stainless steel, viton
Material Standard Sanitary grade; compliantwith FDA and GMP sanitary standards
Warranty 1 year against any manufacturing defects
 
Option Features
Detector Pressure gauge, pressure transducer, temperature transducer
Inlet Type Tri-clamp or luer
Outlet Type Tri-clamp or luer
Nano Membrane 30, 50, 80, 130, 200, 400, 800nm, 1300nm, 2μm, 5μm, 10μm, 20μm, 30μm track-etched membrane (25mm, 47mm, 90mm, 160mm, 293mm)
Multi Extruder Parallel or series connection of multi-extruder
 
1) The Jacketed Liposome Extruder uses compressed air such as nitrogen (N2) as the pressure souce.

The Jacketed Liposome Extruder uses compressed air such as nitrogen (N2) as the pressure souce.
1. Add liposome membrane
2. Add the liposome crude sample from the inlet
3. Connect gas connection with regulator
4. Open the nitrogen and pressure the liposome crude sample through the membrane

2) Please select the suitable gas connection for your nigrogen cylinder

 
CGA580  (USA) United States
G5/8  (UK,CN) United Kingdom, China
DIN477 (GE) Germany
NF E 29-650/C (FR) France
UNI4409 (IT) Italy

adaptor with 3/8-inch male NPT and 1/4-inch female flare outlet
Recommend Uniweld RHP400 Nitrogen Regulator
https://www.amazon.com/Uniweld-RHP400-Nitrogen-Regulator-Connection/dp/B008HQ6GXO?ref_=ast_bbp_dp

3) Warning

Warning
1) Always use regulator, which can be obtained from your gas supplier
2) Before opening the extruder, be sure to shut down the gas and open the relief valve
3) DO NOT point the inlet of the liposome extruder to any person or object a this way raise a safety issue or lead to property loss
4) The user must be responsible in the case of any violation of this clause and recommendation, as well as any other unsafe practices.